Doris Schneider, M. Sc.
Doris Schittenhelm works on biomathematical modelling of metabolic pathways and regulatory mechanisms especially in the context of ROS dynamics and oxidative stress in cells. Besides modelling the cellular metabolism, her main research field is the parametrization of the evolved mathematical models using diverse types of data from in vitro experiments.
She is member of the research group AG Neuss-Radu.
- biomathematical modelling of metabolic pathways and regulatory mechanisms
- ROS dynamics / oxidative stress in cells
- parameterization of mathematical models employing diverse data types from in vitro experiments
- Bayesian model comparison and parameter estimation
- (Markov Chain) Monte Carlo methods
|since 2017||PhD student at FAU Erlangen-Nürnberg under supervision of PD Dr. Maria Neuss-Radu|
|2014–2017||Master’s studies in Integrated Life Sciences, FAU Erlangen-Nürnberg
Mathematical Modelling and Systems Biology
Biological Structures and Processes
Topic of Master’s Thesis:
Mathematical Modelling and Simulation of Response Pathways for Cellular Stress
|2015||Semester abroad at Itä-Suomen yliopisto (University of Eastern Finland) in Joensuu, Finland (ERASMUS+)|
|2011–2014||Bachelor’s studies in Integrated Life Sciences, FAU Erlangen-Nürnberg|
|2011||Abitur at Ostendorfer-Gymnasium Neumarkt i.d.OPf.|
|07/2019 — 06/2020||PhD scholarship “Bavarian Equal Opportunities Sponsorship – Realisierung von Chancengleichheit von Frauen in Forschung und Lehre (FFL) – Realization Equal Opportunities for Women Research and Teaching“|
|07/2018||travel allowance from FAU (Tagungsförderung für Frauen) for participation at ECMTB 2018|
|08/2017||scholarship from The Alan Turing Institute, London, for summer school on Mathematical Aspects of Inverse Problems|
Lectures and Practicals
- Practicals for lecture “Partial Differential Equations for Life Sciences” (SS 18)
- Practicals for lecture “Biomathematics” (WS 17/18)
As a doctoral student, Doris Schittenhelm currently works on a research project about mathematical modelling of response pathways for cellular stress. There, she identifies relevant metabolic pathways and corresponding regulatory mechanisms. From these a mathematical model is deduced and parametrized. Additionally, she develops techniques to estimate parameters from diverse in vitro data and, particularly, evolves a standardized method to analyse fluorescence measurements from a Bayesian perspective especially in the context of cross talk. For this task she applies modern Monte Carlo techniques amongst others. Since July 2019, she obtains the PhD scholarship “Bavarian Equal Opportunities Sponsorship – Realisierung von Chancengleichheit von Frauen in Forschung und Lehre (FFL) – Realization Equal Opportunities for Women in Research and Teaching“.
- “Mathematical modelling of cellular response pathways for oxidative stress”, July 27 2018, ESMTB 2018, Lisbon, Portugal
- 11th European Conference on Mathematical and Theoretical Biology (ECMTB 2018), 23 Jul 2018 – 27 Jul 2018, Lisbon, Portugal
- Summer School: Mathematical Aspects of Inverse Problems, 29 Aug 2017 — 01 Sep 2017, The Alan Turing Institute, London, UK
Dose-response modeling of 3-nitrobenzanthrone-induced alterations of the energy metabolism in urothelial cells
(Third Party Funds Single)Term: 01-01-2017 - 31-12-2018
Funding source: DFG-Einzelförderung / Sachbeihilfe (EIN-SBH)
ROS and pentose phosphate pathway: mathematical modelling of the metabolic regulation in response to xenobiotic-induced oxidative stress and the proposed Impact of the gluconate shunt
In: Free Radical Research 53 (2019), p. 979-992
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